As you advance and the season progresses, your priorities should shift toward Nightmare Dungeons and the Horadric Vault. These high-difficulty dungeons introduce stronger enemies and drop more vials, often in larger quantities. The Horadric Vault is especially noteworthy for its consistent supply of Diablo IV gold valuable resources, including rare spell components and high-level Horadric Vials.

Once you start progressing into the highest levels of the game, Horadric Fortress becomes the ideal location for farming potions and vials. This area provides the best rewards in terms of both vials and other critical materials that will significantly boost your build.

Horadric Vials are the only resource used to upgrade Horadric spells, making them one of the most important items in your inventory. However, it’s crucial to use them wisely.

Don’t rush to upgrade spells too early—especially when you're still experimenting with different abilities. Early on, you’ll unlock a variety of spells and upgradeable components. If you use vials on a spell that you don’t end up using much, it can be a waste. Instead, wait until you’ve tested different spells and solidified your build before investing your vials. This way, you’ll be able to upgrade the spells you’re actually going to use in the long run, maximizing the benefit of each vial spent.

Another option for enhancing your spells is Horadric Jewelry. This equipment type boosts your spell power, but like spell upgrades, it’s wise to wait before crafting jewelry. Don’t rush into crafting jewelry until you’re certain about which spells you prefer, as cheap Diablo 4 Items this will prevent you from wasting materials on suboptimal gear.